Archived from the original on 23 April 2011. ^ "Is Viagra about to lose its pulling power in the UK?". Archived from the original on 30 October 2013. Archived from the original on 22 August 2009.
| Condition | Caution / Notes | Risk Factors |
|---|---|---|
| Cardiovascular disease | Use with caution | Heart failure, recent MI |
| Concomitant nitrate use | Absolute contraindication | Risk of severe hypotension |
| Severe hepatic impairment | May require dose adjustment | Reduced clearance |
| Retinitis Pigmentosa | Cautious use | Potential for vision disturbances |
Archived from the original on 25 June 2007. "Viagra from the pharmacist: insight from reclassification in New Zealand". Archived from the original on 17 May 2021. ^ "Generic Viagra developers queue up, but may have to wait".
See also:
^ "Set to conquer US, Indian 'Viagras' may give Pfizer a hard Time". Archived from the original on 22 December 2020. ^ a b "Pfizer Settles Viagra® Patent Litigation With Teva". "Lockout Supplements Issues Voluntary Nationwide Recall of Boner Bears Chocolate Syrup Due to Undeclared Sildenafil". Archived from the original on 19 November 2016.
Cessation and Adverse Effects of Treatment
"Counterfeit Viagra, Cialis, Levitra: The Ultimate Guide". Archived from the original on 10 January 2017. "Online pharmacies suspected of counterfeit drug sales". ^ "Erectile Dysfunction Medication the Most Seized Drug During Global Crackdown, Interpol Says". ^ "Global illicit medicines targeted by INTERPOL operation". Archived from the original on 28 December 2021. ^ "Approved Viagra copies flood drugstores in Korea". ^ "Viagra prescriptions almost triple in a decade". Archived from the original on 1 July 2024.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 150mg | 360 + 10 Pills | 423.48€ 403.31€ | |
| Viagra Generic | 25mg | 30 + 4 Pills | 47.97€ 45.69€ | |
| Viagra Generic | 50mg | 20 Pills | 40.52€ 38.59€ | |
| Viagra Generic | 50mg | 10 Pills | 26.87€ 25.59€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Viagra Generic | 200mg | 20 Pills | 61.69€ 58.75€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Kamagra Polo | 100mg | 60 + 4 Pills | 189.39€ 180.37€ | |
| Viagra Generic | 200mg | 60 + 4 Pills | 125.19€ 119.23€ | |
| Kamagra Soft Tabs | 100mg | 32 Pills | 120.11€ 114.39€ | |
| Viagra Generic | 25mg | 180 + 6 Pills | 154.93€ 147.55€ | |
| Kamagra Polo | 100mg | 32 Pills | 125.88€ 119.89€ | |
| Viagra Generic | 150mg | 270 + 10 Pills | 326.61€ 311.06€ |
^ "MHRA reclassifies Viagra Connect tablets to a Pharmacy medicine".
LinkOut - more resources
Archived from the original on 10 March 2013. "Canadian Supreme court rules Viagra patent invalid". Archived from the original on 11 November 2012. ^ "Viagra patent tossed out by Supreme Court: Decision allows generic versions of drug to be produced". Archived from the original on 18 September 2013.
Sildenafil Tablets or Oral Suspension for PAH
^ "Pfizer Canada drops Viagra price after generic versions get Supreme Court green light". Archived from the original on 30 November 2012. Archived from the original on 27 December 2013. "In rare move, Pfizer asks Supreme Court to reconsider ruling that killed Viagra patent". Archived from sildenafil 25mg tablets the original on 5 February 2013. ^ "Viagra to be available without prescription in UK". A service of the National Library of Medicine, National Institutes of Health.
- Always consult a healthcare provider before starting sildenafil.
- Do not exceed the prescribed dose to avoid side effects.
- Sildenafil can interact with nitrates, causing dangerous blood pressure drops.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
- Some men may experience minor flushing after taking sildenafil.
- If an adverse reaction occurs, stop medication and contact your doctor.
- Be aware of possible symptoms like sudden vision loss.
To examine the effectiveness, safety and cost-effectiveness of sildenafil for the treatment of male erectile dysfunction. MEDLINE (1966 to June 1998), EMBASE (1988 to June 1998), Cochrane Library (Issue 3, 1998), PsycLIT (1996 to 1987 (sic)), National Research Register Interim version June 1998 and Pharm-line were all searched for articles containing the free-text terms "sildenafil" or "Viagra". The main Internet search engines were used using the terms "sildenafil" or "Viagra".
Chemical synthesis
"The Supreme Court of Canada holds Pfizer's Viagra patent invalid". Archived from the original on 20 May 2013. ^ "Actavis Launches Generic Viagra in Europe as Patents Expire". Archived from the original on 29 October 2013. "What Will Happen When Viagra Goes Generic?". The FDA centre for Drug Evaluation and Research, Joint Clinical Review for NDA-20-895 Viagra (Sildenafil), the BMJ, Lancet, JAMA, New England Journal of Medicine, BJGP, Drug, Inpharma and Scrip were all handsearched.
What other drugs will affect sildenafil?
Archived from the original on 10 December 2023. ^ "Israeli-made AI exposes international fake Viagra network". ^ "Counterfeit Viagra Pills, Footwear, Belts, Car Emblems and Headphones Worth over $32 Million Seized at the LA/Long Beach Seaport U.S. Customs and Border Protection". Archived from the original on 12 October 2013.
The International Index of Erectile Function
"Yes, There Is a Way to Get Generic Viagra". Archived from the original on 2 May 2016. "Pfizer Wins Viagra Patent Infringement Case Against Teva Pharmaceuticals". Archived from the original on 11 January 2015. ^ "Pfizer Completes Transaction sildenafil citrate 200mg price to Combine Its Upjohn Business with Mylan". Experts in the field and the manufacturers (Pfizer Ltd) were contacted. Reference lists of all relevant studies identified were scanned. The Science Citation Index was searched using all relevant studies identified.
Access options
"Sales of Impotence Drugs Fall, Defying Expectations". Archived from the original on 11 October 2007. ^ "Pfizer Courting More Controversy with Viagra 'Advergaming'". Archived from the original on 19 December 2019. Archived from the original on 6 May 2018.
What should I know about sildenafil before taking it?
Archived from the original on 9 January 2009. Archived from the original on 22 February 2021. ^ a b "Viagra now available over the counter without prescription in the UK". Archived from the original on 26 March 2021. Archived from the original on 8 December 2013. Both Phase II and Phase III studies were included. The authors planned to compare sildenafil to other current treatments for erectile dysfunction, but no evidence was found. The review did not specify inclusion criteria for participants, but all included studies recruited men aged 18 years and over with erectile dysfunction of at least 6 months duration, in a heterosexual relationship for at least 6 months: aetiology included diabetes and spinal cord injury. Men with the following disorders were excluded: anatomical deformities; other sexual disorders; elevated prolactin (3xULN) or low free testosterone (20% below LLN); major uncontrolled psychiatric disorders; history of alcohol or drug abuse; history of major haematological, renal or hepatic disorder; stroke or MI within 6 months; cardiac failure, unstable angina, ECG ischaemia or life threatening arrhythmia within 6 months; BP outside the range 90/50 to 170/100 mmHg; active peptic ulcer disease of bleeding disorder; clinically significant baseline laboratory abnormality; need for anticoagulants, nitrates, androgen or trazodone; need for aspirin or NSAIDs and history of peptic ulcer disease; unwillingness to cease using other therapy for erectile dysfunction; other experimental drug use within 3 months; history of retinitis pigmentosa. The review did not specify which outcomes included studies should measure. Phase II trials measured penile rigidity (using a Rigiscan) during visual or vibratory sexual stimulation. Phase III and some Phase II trials measured outcomes using the International Index of Erectile Function (IIEF): a self-administered questionnaire sildenafil tables consisting of 15 questions around 5 domains of male sexual function: erectile function, orgasmic function, sexual desire, intercourse satisfaction, overall satisfaction. The authors do not state how many of the reviewers performed the selection. TTwo independent reviewers performed the validity assessment, but the method they used was not reported. The following aspects of validity were considered in the 'Results' section: blinding, control group, sample size, loss to follow-up. Two reviewers extracted data from all trials independently into pre-defined tables. Data were extracted on: source of information; cause of erectile dysfunction; number of patients; patient characteristics; treatments; duration; outcomes; p values; date of study. A narrative synthesis, with some pooling where mean scores (for response to questions) and mean proportions are presented. The methods used to combine data are not presented in the report. No formal investigation of heterogeneity was carried out. Seven were Phase III trials and 14 were Phase II trials. Penile rigidity (Phase II trials only, n=7): In all studies an increased duration of rigidity >60% was seen with increasing doses of sildenafil. Frequency of penetration: 9/9 RCTs showed statistically significant improvements with all doses of sildenafil compared to placebo. Increasing improvement was apparent with increasing dose over the range 25-100mg. Maintenance of erection after penetration: 9/9 RCTs showed a statistically significant improvement with all doses of sildenafil compared to placebo. General efficacy question: 21/21 RCTs reported an improvement in erections with sildenafil treatment (65-82% improved) compared to placebo (18-26% improved). A dose-response relationship was seen over the dose range 25-100mg. Successful intercourse: Proportion of attempts at intercourse that were successful with sildenafil treatment increased compared to placebo treatment (6/9 RCTs list a positive outcome). One RCT found no increase in rates of attempted intercourse with sildenafil, despite increased success rates.
What side effects can this medication cause?
"The coming generics threat to Pfizer's Viagra brand just got scarier". Archived from the original on 9 September 2017. ^ "Viagra to go generic in 2017 according to Pfizer agreement". Archived from the original on 1 December 2017. "Sex, Drugs and That Little Blue Pill".
Professional resources
Archived from the original on 6 December 2017. "Why Pfizer Is About to Slash Viagra's Price in Half". Archived from the original on 7 December 2017. "Pfizer to lose patent of drug Viagra, Indian companies gear up with copycat versions: Pfizer's patent for the formulation of Viagra, used to treat impotence in men, ends in the US in 2020". Archived from the original on 17 April 2021. Erections hard enough for intercourse: In 6/6 RCTs a significant improvement in the number of grade 3 and 4 erections was seen with sildenafil treatment. Partner's questionnaire: Generally increasing partner satisfaction was seen with increasing sildenafil dose (10-100mg). Quality of life: Statistically significant but small quality of life treatment effects were seen in 4 RCTs.
Further information
Retrieved 17 June 2024 – via Business Wire. Archived from the original on 17 June 2024. "Viagra patent expires in June, says Brazilian court". Archived from the original on 17 April 2012. ^ "Revatio patent ruled invalid for lack of sound prediction and obviousness".
Outcomes assessed in the review
Archived from the original on 3 March 2016. {{cite web}}: CS1 maint: deprecated archival service (link) ^ Teva Canada Ltd. v. Pfizer Canada Inc., 2012 SCC 60 at par. "Supreme Court ruling could lead to cheaper versions of Viagra". Adverse effects: Adverse events reported in >2% (range 2% - 10%) of patient treated (2RCTs) include headache, flushing, dyspepsia, nasal congestion, urinary tract infection, abnormal vision, diarrhoea, dizziness, rash, respiratory tract infection.